Simparica Chewables for Dogs Above 88LBS [Red] remains effective for 35 days. It kills ticks within 8 hours and fleas within 3 hours of administration. This treatment is effective against fleas, ticks, Sarcoptic mange, and ear mites. Buy Flea and Tick Preventive Online. Save an extra 10% with auto-order and get free shipping. Apply Coupon Code: 4THJULY