For American Airlines seat selection typically opens up at different times depending on various factors. For instance, passengers booking basic economy tickets might have to wait until check-in to choose seats, while those with higher-tier memberships or purchased seats in advance can select them at the time of booking. Additionally, seat availability may vary depending on the flight's popularity and capacity. To secure preferred seats, it's advisable to book early or consider purchasing a higher fare class. American Airlines provides flexibility to passengers, allowing them to tailor their travel experience by choosing seats that best suit their preferences and needs.